Nicotinamide adenine dinucleotide (NAD)-What is it?

Life would cease to exist without the NAD molecule. It is used as fuel by multiple enzymes in the body for the brain, muscles, immune system, and for all energy production. NAD deficiency is associated with type 2 diabetes, Alzheimer’s, obesity, cardiac and cerebral ischemia, mitochondrial dysfunction, and overall aging.  NAD is sometimes called the “molecule of youth” because levels of NAD dramatically drop as humans age.

 So how can we boost our levels naturally with IV Therapy?

  • Energy stressors will stimulate NAD production. These including fasting, caloric restriction, and exercise.
  • Certain foods can initiate NAD production including salmon, spinach, lean meats, legumes, and nuts. It is important to note though, that dietary intake is not the main source for NAD because the body’s demand for NAD exceeds its capacity to produce it. The body uses a recycling pathway within the body to keep up with production.
  • The main enzyme in this recycling pathway in NAMPT. Resveratrol supplementation, calorie restriction, fasting, and exercise have been found to increase NAMPT levels. This molecule also has a diurnal peak, with levels peaking in the early afternoon, so it is best to utilize these promoters in the morning to early afternoon.
  • Supplements in the form of precursors and have been found in studies to aid in the synthesis of NAD. These are nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and niacin. NMN is harder on a budget with a quality supplement costing about $5 per day.

When boosting NAD levels, natural by-products will occur. These are called metabolites. Methylation is the process by which these metabolites are formed. This draw from the body’s natural methyl pool. Because methyl groups are required for many other functions including neurotransmitter and DNA, it is important to replenish methyl groups especially when taking higher doses of niacin, NMN or NR. It is suggested that niacin be taken concurrently with trimethyl glycine (TMG) at a1:1 ratio. For NMN or NR the ratio would be 1: ½.


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